2286
نویسندگان
چکیده
منابع مشابه
PReS-FINAL-2286: Mastitis in an adolescent patient with juvenile systemic lupus erythematous
Methods: Case report A 16 year-old girl presented with a painful left breast mass associated with localized skin erythema. Her medical history was significant for diffuse proliferative lupus nephritis that was diagnosed in 2002. After 2 years of immunosuppression therapy, the patient had stable renal function for more than 8 years. In January 2013, she presented with a painful nodule in the lef...
متن کاملA Novel PARP Inhibitor L-2286 in a Rat Model of Impact Acceleration Head Injury: An Immunohistochemical and Behavioral Study
We examined the neuro/axono-protective potential of a novel poly (ADP-ribose) polymerase (PARP) inhibitor L-2286 in a rat impact acceleration brain injury model. Male Wistar rats (n = 70) weighing 300-350 grams were used to determine the most effective intracerebroventricular (i.c.v.) dose of L-2286 administered 30 min after injury, and to test the neuroprotective effect at two time points (imm...
متن کاملModern strategies in electroorganic synthesis.
4.2. Solid-Supported Electrolytes 2280 4.3. Solid-Supported Mediators 2282 4.4. Supported Substrate-Product Capture 2283 4.5. A Unique Electrolyte/Solvent System 2285 5. Reaction Conditions 2285 5.1. Supercritical Fluids 2285 5.1.1. Electrochemical Properties of scCO2 2285 5.1.2. Electroreductive Carboxylation in scCO2 2286 5.1.3. Electrochemical Polymerization in scCO2 2286 5.2. The Cation-Poo...
متن کاملPARP-Inhibitor Treatment Prevents Hypertension Induced Cardiac Remodeling by Favorable Modulation of Heat Shock Proteins, Akt-1/GSK-3β and Several PKC Isoforms
Spontaneously hypertensive rat (SHR) is a suitable model for studies of the complications of hypertension. It is known that activation of poly(ADP-ribose) polymerase enzyme (PARP) plays an important role in the development of postinfarction as well as long-term hypertension induced heart failure. In this study, we examined whether PARP-inhibitor (L-2286) treatment could prevent the development ...
متن کاملThe role of Akt and mitogen-activated protein kinase systems in the protective effect of poly(ADP-ribose) polymerase inhibition in Langendorff perfused and in isoproterenol-damaged rat hearts.
Blocking poly(ADP-ribosyl)ation of nuclear proteins protects the heart from ischemia-reperfusion injury. In addition, activation of Akt and mitogen-activated protein kinase (MAPK) cascades also plays a pivotal role in the survival of cardiomyocytes during ischemia-reperfusion; however, the potential interplay between these pathways is yet to be elucidated. We therefore tested the hypothesis whe...
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ژورنال
عنوان ژورنال: Journal of Clinical and Translational Science
سال: 2017
ISSN: 2059-8661
DOI: 10.1017/cts.2017.65